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WebOct 14, 2005 · Here, we show that Akt phosphorylates EZH2 at serine 21 and suppresses its methyltransferase activity by impeding EZH2 binding to histone H3, which results in a decrease of lysine 27 trimethylation and derepression of silenced genes. Our results imply that Akt regulates the methylation activity, through phosphorylation of EZH2, which may ... WebSynonyms for aspersions include slander, defamation, libel, calumny, vilification, calumniation, smearing, aspersion, maligning and libeling. Find more similar words ... WebTumors were mainly located in the brainstem, ATRX thalamus, and spinal cord, but also in the cerebellum, corpus callosum, and the lateral ventricle. Patients with H3 K27M-mutant … sq ft concrete