Hyperphagic mice
Web14 apr. 2024 · Genetically modified mouse models lacking MCH or having disrupted the MCH-R1 gene are lean, hyperphagic, and have elevated energy expenditure (Takase et al., 2014). On the other hand, transgenic mice overexpressing the MCH gene develop hyperphagia, mild obesity, and insulin resistance (Ludwig et al., 2001). Anorexigenic … Web6 aug. 2014 · Hypothalamic miR-103 protects from hyperphagic obesity in mice. The role of neuronal noncoding RNAs in energy control of the body is not fully understood. The …
Hyperphagic mice
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WebPsychoneuroendocrinology Apr 2014. Abstract. Although second-generation antipsychotics induce severe weight gain and obesity, there is a lack of detailed knowledge about the progressive development of antipsychotic-induced obesity. This study examined the hypothalamic histamine H1 receptor and AMP-activated protein kinase (H1R-AMPK) … WebHafnia alvei HA4597 significantly reduces overall weight gain in hyperphagic mice on a high-fat diet, and improves glycemia levels compared to the high-fat diet and to the Orlistat group. 2. Clinical evidence: efficacy confirmed through a clinical trial at …
Web1 jul. 2014 · Germline haploinsufficiency of human or mouse Sim1 is associated with hyperphagic obesity.Sim1 encodes a transcription factor required for proper formation … WebMice were treated with vehicle or pAkk for 4 wk, starting 3 days before ovx or sham surgery. Treatment with pAkk reduced fat mass… Other authors See publication Supplementation with Akkermansia...
Web6 jan. 2015 · Importantly, hyperphagia arises spontaneously in subordinate mice and under a high-fat diet it is associated with vulnerability to obesity, metabolic-like, and type-2 … Web14 jun. 2024 · Using a hyperphagic mouse fed with Western diet (WD), we aimed to elucidate the cross-talk and kinetics of hepatic and extra-hepatic alterations during NASH …
WebPVN neurons in Sim1(+/-) mice are hyporesponsive to the melanocortin agonist melanotan II. PVN neuropeptides oxytocin (Oxt), TRH and CRH inhibit feeding when …
Web1 mrt. 2002 · Failure of NPY-deficient mice to suppress melanocortin signaling may therefore have contributed to the attenuation of their hyperphagic response. Moreover, … eric fausch rapid cityWebData show that Rai1+/- mice are hyperphagic, have an impaired satiety response and have altered abdominal and subcutaneous fat distribution, with Rai1+/- female mice having a … eric fauryWeb9 mrt. 2024 · In vivo, Adig −/− mice are leaner than wild-type mice when fed a high-fat diet and when crossed with Ob/Ob hyperphagic mice. In addition to the impact on fat mass … eric favors shot putWeb1 sep. 2024 · Importantly, compared with weaning db/+ mice (lean control), the hyperphagic db/db mice of the same age have markedly increased weight, adipose … eric fast greenwich ctWeb31 jan. 2024 · Growth hormone has a role in determining mouse trabecular bone mass; its effect is gender-specific. first in vivo evidence that Zn-16 mRNA abundance correlates … eric faxhagWebJNK in the anterior pituitary gland promotes obesity and insulin resistance. We examined the body mass of P WT and P ΔJ1,J2 mice when fed a normal chow diet (ND) or a HFD for 16 wk. No significant difference in total body mass was detected in ND-fed mice, but the JNK-deficient mice exhibited markedly decreased body mass compared with P WT mice … eric fausch md rapid city sdWebThienopyrimidinone bis-aminopyrrolidine ureas as potent melanin-concentrating hormone receptor-1 (MCH-R1) antagonists eric favory